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This has important clinical consequences, such as the lack of biological markers [7] and the hindered development of targeted pharmacological treatments

One of these commenters reviewed the alternative derived weights from the most recent PPI and CPI survey data for the GPCIs and found them problematic and agreed with CMS' reasons for maintaining the current 2006 MEI cost share weights

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When someone experiences persistent levels of stress and thus increased cortisol, they may experience dysregulation of neurotransmitters such as dopamine, serotonin, and norepinephrine