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Intestinal oxidative stress associated with excessive ROS generation causes oxidative modifications to tight junction proteins leading to increased intestinal permeability, invasion of luminal bacteria, and gut dysbiosis

Members of the mitochondrial solute carrier (SLC) family 25 (SLC25) provide transport steps for substances across the mitochondrial inner membrane into the mitochondria that are needed for biochemical pathways and cellular homoeostasis

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As he argued, 'the pancreas is capable of exerting a regulatory influence on the blood sugar level in both directions' (Ferner)

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