Neuroscience 2009, 158, 514-523, doi:10.1016/j.neuroscience.2008.10.041
Patients should contact their GP urgently if experiencing severe abdominal pain, persistent vomiting, difficulty swallowing, or unexplained weight loss
This can cause fatigue, weakness, and shortness of breath
For instance, liraglutide (Victoza), dulaglutide (Trulicity), and subcutaneous semaglutide (Ozempic) have data supporting risk reduction of major adverse cardiovascular events as well as preserving kidney function in patients with T2DM.(2)(3)(4) Another benefit of GLP-1 and GIP/GLP-1 receptor agonists is significant weight loss, specifically seen with liraglutide, semaglutide, and tirzepatide, which are now available as FDA approved products for weight management with the brand names Saxenda, Wegovy, and Zepbond respectively.(5)(6)(7) While these products have great glycemic, weight, and cardiovascular outcomes, the benefits have resulted in some detrimental repercussions
Estradiol increases glucose availability and ATP production in neuronal mitochondria (205)
