Deficiency leads to hypothyroxinemia and, in severe cases, congenital iodine deficiency syndrome characterized by irreversible cognitive impairment (143, 144)
However, FDA has separately identified product quality as a documented concern category for compounded GLP-1 products generally, including contamination and variable potency
The FDA warned against the use of compounded semaglutide more broadly, noting that these reformulated therapies pose a higher risk to patients than approved medicines because they do not undergo FDA premarket review for safety, effectiveness or quality. Patients should only be on compounded medication if their medical needs cannot be met by an available FDA-approved drug. Weight-loss therapies have been growing rapidly in recent months, with Novo Nordisks Wegovy (semaglutide) and Eli Lillys Zepbound (tirzepatide) currently dominating the space and other competitors looking target the lucrative market
These additives can sometimes interfere with absorption or add an unnecessary burden to the very organs you are trying to support
(5) current research must focus on the development of drugs that penetrate the BBB, facilitate cognitive processing, and protect against the loss of synapses and neurons
