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Regarding other proteases, trypsin and furin can cleave MERS-CoV and SARS-CoV-2 S proteins at the same site 10,15,30,42 and trypsin cleaved the RaTG13 S protein at the S1/S2 cleavage site (at R685/S686 in SARS-CoV-2), whereas trypsin also caused much small fragment derived from S2

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This characteristic has allowed researchers to study its systemic biological effects across multiple experimental models