Y250 is located much farther from the disulfide bonds (Cys128-Cys206 in the hinge region between K1 and K2 domains, and Cys211-Cys288, Cys232-Cys271, and Cys260-Cys283 in the K2 domain) than the distances between Y198 and disulfide bonds, Cys149-Cys189 and Cys177-Cys201
MS is responsible for the regeneration of methionine (Met) from homocysteine (Hcy) in the methionine cycle (see Figure 1)
Physiological ovarian aging (NOA) is the gradual loss of ovarian reserve function in older women until they reach menopause while pathological ovarian aging is the premature ovarian failure caused by various pathogenic factors, including decreased ovarian reserve (DOR), ovarian insufficiency (POI) and poor ovarian response (POR) (41)
Selenium status in the body and cardiovascular disease: a systematic review and meta-analysis
Zinc is also involved in the production of metallothionein, and a deficiency in zinc can lead to decreased metallothionein production, further exacerbating copper overload