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Insulin/IGF-1 signaling promotes immunosuppression There is convincing evidence that insulin/IGF-1 signaling inhibits inflammatory responses not only by reducing pro-inflammatory hyperglycemia but also by modulating the immune system and decreasing the generation of inflammatory mediators [6]

2024;DOI:10.1001/jamainternmed.2024.466.

3,4 This receptor and its agonists hold significant therapeutic potential, reshaping the treatment approaches for multiple diseases, including diabetes, cardiovascular disorders, and neurodegenerative diseases

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