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This process triggers a potent inflammatory response, characterized by the upregulation of pro-inflammatory cytokinesincluding IL-1 and interferon- (IFN-)and the concomitant downregulation of tight junction proteins, thereby compromising mucosal barrier integrity 76

Zavitsanou, A.-M

This pharmacokinetic profile supports the medication's mechanism of action, which includes enhancing glucose-dependent insulin secretion, suppressing inappropriate glucagon release, slowing gastric emptying, and promoting satiety through central nervous system pathways

In a crossover study of 74 healthy adults who received a single 80-mg isotretinoin dose (as two 40-mg capsules) under fasted and fed conditions, both the peak plasma concentration and total area under the plasma concentration-time curve (AUC) of the drug were more than doubled when isotretinoin was administered immediately after a standardized high-fat meal compared with administration in the fasted state