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Cancer Lett 377(2):117125
Additionally, VC inhibits HIF1a transcription and increases HIF1 alpha-hydroxylase activity, leading to mitochondrial activation (115) and antioxidant effects
10.1007/s004010000202 Acta Neuropathol
Moreover, there is a necessity for additional animal and human intervention studies to ascertain the efficacy of selenium compounds in chemoprevention strategies and their potential to obstruct the metastatic cascade of cancer
Interestingly, loss of muscle mass in itself appears not to be associated with functional decline and disability [51] but rather maintenance of muscle strength is key to preventing functional decline [52], with randomised controlled trials (RCTs) demonstrating the benefit of resistance training in older adults [53]
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