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Monitor your hair from the start, noting if you already have thinning areas, and tracking hair shedding (particularly considering the timing, as this could indicate telogen effluvium)

The evidence supporting reduced side effects comes from three sources: pharmacokinetic modeling, anecdotal reports, and inference from studies on GI tolerability during dose escalation

Lowering blood sugars, in part by reducing the production of sugar in the liver

People with a history of pancreatitis, severe gastrointestinal disease, or diabetic retinopathy may need an alternative approach

Third, it focuses attention on the tolerability challenge: greater potency appears to come with a higher side effect burden, and the field must determine how to preserve efficacy while improving patient retention [5]