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Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2

GR stands for glutathione reductase and it's an enzyme that converts oxidized glutathione into a more active, bioavailable version of glutathione, known as 'reduced glutathione'

The application contained data from the Phase III FOCUS study, a single-arm, open-label trial which enrolled 91 patients who were treated every six to eight weeks for up to a maximum of six cycles

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