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In parallel, CLOCK-BMAL1 recruits CUL4A-DDB1 to circadian target genes such as PER1, PER2, and CRY1, where it catalyzes rhythmic histone H2B monoubiquitination at E-box sites (Tamayo et al., 2015)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 168.Pistorio M.L., Moretta T., Musumeci M.L., Russo C., Lacarrubba F., Petralia A., Micali G., De Pasquale C

Figures are population averages for illustration, not individual predictions