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In clinical trials, pharmaceutical-grade probiotics have shown to improve gut bacteria

Neural pathway changes The brain reward circuitry changes in response to weight loss, making calorie-dense foods more rewarding and harder to resist

Parkinsons Dis 2020 Mar 24;2020: 2020

This, in turn, increases insulin-like growth factor-1 (IGF-1), a hormone that encourages muscle protein creation and fat breakdown

Targeting HDACs with HDACi might have potential for treatment of neurological disorders such as Huntington's disease, Alzheimer's disease, amyotrophic lateral sclerosis, seizure disorders, spinal muscular atrophy, Rett syndrome, stroke, Fragile X syndrome, and Rubinstein-Taybi syndrome (Saha and Pahan, 2005)