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In addition to important role in the folate cycle that is involved in the reduction of BH 2 to BH 4 , it is an important component in homocysteine metabolism via the methionine cycle (Figure 8), and is critical for neural tube development

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To generate reducing equivalents, in the form of NADPH, for reductive biosynthesis reactions within cells

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The high demand and high cost of these medications create incentives for inappropriate prescribing, prescription diversion, or attempts to obtain medication without proper clinical evaluation