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This metabolic network allows T cells to adapt to microenvironmental cues, with distinct lipid utilization patterns favoring either effector or regulatory phenotypes (92)

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Additionally, it has been uncovered that NRF2 improves the chemosensitivity of tumor cells to sorafenib-induced ferroptosis [90]

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In summary, combining structural data from cryo-EM, receptor mutagenesis, pharmacological assays and MD simulations advances our understanding of peptide agonist engagement with the GLP-1R