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By contrast, Compound C decreased insulin secretion, which could be reversed by EX-4 co-treatment (Figure 2E)

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Cells null for Notch1 were derived from conditional Notch1 fl/fl -Rosa26 YFP mice 33 , recombined with adenoviral Cre recombinase as above, and placed in mixed epithelioid culture with unrecombined cells from the same animal

Regulatory approvals are pending