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Sulfonylureas stimulate insulin secretion by closing ATP-sensitive potassium channels in pancreatic cells, while thiazolidinediones activate peroxisome proliferator-activated receptor-gamma (PPAR-) to improve insulin sensitivity

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Something I often tell my patients is that many of the changes or habits they can use to help limit side effects of GLP-1 are also habits that can help them improve health and keep weight off in the long run, like the post-meal walks, chewing slowly, and not eating quickly, as well as avoiding fried foods and some of the fizzy drinks

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