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doi: 10.1016/j.cell.2018.08.046 45 Dos SantosJFRPassetiTPetriGde AlmeidaAHda VeigaGLVeridianoJet al

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This study examined the hypothesis that GSH-deficiency induces epigenetic alterations of VD metabolism genes, which can reduce the circulating 25(OH)VD 3 levels in obesity

Daily administration would produce accumulating plasma levels far beyond the studied range, dramatically increasing side effects without proportional benefit

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