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In follicular macrophages from RA, upregulation of the BCAA transporter SLC7A5 is closely associated with activation of the mTORC1 signaling pathway, which in turn promotes M1 macrophage polarization and arthritic tissue damage (87)

In the first few hours after the procedure, rest and self-care are very important

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All samples were dispatched to MetaMetrics Laboratory in frozen condition (20 C) every two weeks and stored for no more than 1.5 months before analysis

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