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In rodent models, effective doses range from 0.5 mg/kg/day (intraperitoneal) to 2 mg/kg/day (oral) for cognitive function studies

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Most concluded that the substance appears quite promising, but that there are too many unknowns to justify its clinical use at this time

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Publication Bias Positive findings are generally more likely to be published than negative studies

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Typical drug development paradigms that target single proteins insufficiently address this challenge [14,15,16,17]

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