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GLP-1 receptor activation inhibits hunger-promoting neurons while stimulating satiety-promoting neurons, creating a coordinated anorexigenic effect

10.3389/fendo.2021.721135 Front

In 2024, semaglutide 2.4 mg (Wegovy) received FDA approval for cardiovascular risk reduction in adults with established cardiovascular disease and either overweight or obesity, based on the SELECT trial

The Grading of Recommendations Assessment, Development and Evaluation framework (GRADE) system was applied to assess the certainty of evidence for each outcome

GLP-1 may also affect systemic energy metabolism by stimulating thermogenesis in brown adipose tissue and browning of white adipose tissue [43]