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The KCH in London, United Kingdom developed a prognostic model based on two groups of patients, those with APAP-induced acute liver failure and those with non-APAP-induced acute liver failure

Studies were included if they investigated patients aged 18 years or older who were critically ill and receiving ICU treatment or those who had sustained trauma or burns requiring treatment

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A controlled study (PMID: 7777652) found that DSIP did not significantly affect CRH- or meal-induced ACTH and cortisol secretionindicating DSIP does not measurably blunt the human cortisol response, contrary to stress-protective effects suggested by some animal studies