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Contamination: The biggest risk is the introduction of bacteria or other contaminants

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Quantitative endpoints, such as MRI-PDFF and histology, can capture subtle yet clinically meaningful changes, whereas ALT/AST and ultrasonography may miss early metabolic improvements

The activation of GLP-1R promotes the release of -endorphins, which mediate analgesic effects through receptors at the neuronal level [39, 42]