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Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): a randomized, open-label study

This histologic improvement is vital for managing MASH, as it can prevent the progression to more severe liver diseases

In addition, GLP-1 RAs can improve cardiovascular outcomes, thought to be independent of the antihyperglycaemic effects

The FDA cleared orforglipron for chronic weight management in adults with obesity, or overweight with at least one weight-related comorbidity, based on the ATTAIN clinical program which showed placebo-adjusted weight loss of 7.5% to 11.2% in non-diabetics (ATTAIN-1) and 5.1% to 9.6% in diabetics at different doses, along with the expected glycaemic benefits (ATTAIN-2)

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