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R The clinical relevance for detoxification: Met/Met individuals have reduced capacity to methylate and inactivate catechol estrogens (2-OH and 4-OH estradiol)

We exposed cell lines that had either Keap1, Nrf2 or Srxn1 tagged with green fluorescent protein (GFP) to a concentration range of DEM and monitored the response of these Nrf2 pathway components using high throughput confocal imaging (Fig

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Diastolic blood pressure also improves, though the effect is somewhat smaller than systolic improvements