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Moving forward, a combination of targeted metabolic inhibitors, engineered immune therapies, and bioinformatics-guided treatment strategies offers substantial potential for disrupting CSC-driven tumor progression and improving long-term patient outcomes

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The APLN/APLNR signaling pathway is involved in developmental angiogenesis, where the APLNR expression is predominantly restricted to the ECs of the developing vascular system and APLN regulates vascular patterning in the embryo [172,173,174]

As mentioned before, the diet uses meal replacements to create a calorie deficit to facilitate weight loss