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Across polyphenol subclasses, a recurring mechanistic theme is the concurrent suppression of NF-B-mediated inflammatory signaling and activation of the PI3K/Akt/GSK-3 pathway, which together reduce muscle catabolism, improve glycogen metabolism, and maintain mitochondrial membrane integrity during exercise

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Substituting one for another may change the peptides solubility profile, particularly for longer sequences, hydrophobic peptides, modified peptides, or peptides with specific salt forms

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