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The first experiment showed no significant changes in heart rate or BP after GLP-1RA administration, whereas the second experiment revealed a statistically significant increase in muscle sympathetic nerve activity (p0.05)

29 In children aged six to 12 years with nonsyndromic obesity, liraglutide 3 mg daily for one year produced a 7.4% reduction in BMI compared with placebo

Chaudhari DD, Singh R, Mallappa RH, Rokana N, Kaushik JK, Bajaj R, et al

Acknowledgements We thank LC Sciences (Hangzhou, Zhejiang, China) and Majorbio Co., Ltd (Shanghai, China) for assisting with single-cell RNA sequencing (scRNA-seq) and bioinformatics analysis