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doi: 10.1038/nn.4030 409 SanmarcoLMWheelerMAGutierrez-VazquezCPolonioCMLinnerbauerMPinho-RibeiroFAet al

This triple-agonist approach creates a synergistic effect that exceeds what any single-target therapy can achieve

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Thus, the UPS is a vital first-line component of PQC, and HSC70 is well known to recruit it when it joins its co-chaperone, CHIP (Shimura et al., 2004

Nearly all Bacteroides and Proteobacteria can produce pantothenic acid and CoA (Magnusdottir et al., 2015)