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Gastrointestinal symptoms of this include abdominal pain and distention, nausea, and diarrhoea, and vasomotor effects can include diaphoresis, palpitations, weakness and flushing [9, 11]

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doi: 10.1371/journal.ppat.1006654 129 FrisoniG

From there, it distributes throughout the body and reaches dermal fibroblasts from the inside