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GHK-Cu provides broader systemic benefits and strong mechanistic rationale but requires accepting the limitations of its research compound status

The activated Trem2 signal in stage 1 DAM facilitates transition to stage 2 DAM, which is characterized by an upregulation of lysosomal, phagocytic, and lipid metabolism pathway-related genes including cst7 and itgax

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Copper can enhance expression of MMP-1, an enzyme that breaks down collagen