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Estrogens, in turn, have negative feedback effects on the hypothalamic-pituitary-gonadal axis, first lowering gonadotropin-releasing hormone (GnRH), which in turn lowers both gonadotropins, follicle stimulating hormone (FSH) and luteinizing hormone (LH) [36]

And I think it it relates, Suzanne, to a comment I think you made earlier

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Although there are some inter-class differences, robust randomized controlled trials have demonstrated that use of some of these drugs can improve clinical outcome in individuals with T2D

Who Shouldnt take Ashwagandha People with a diagnosed liver disease : Ashwagandha has rarely been reported to be associated with liver issues (hepatitis) which could lead to jaundice and/or liver damage, especially in people who already suffer from liver disease