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Preclinical and early human data suggest glucagon receptor activation may increase energy expenditure, stimulate hepatic lipolysis, reduce liver fat accumulation, and elevate basal metabolic rate

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This approach may help restore gut homeostasis while simultaneously creating an environment less hospitable to methane-producing organisms, making butyrate supplementation a logical therapeutic consideration for IMO cases

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Pediatric patients 12 years of age or older with an initial BMI at the 95 th percentile or higher for age and sex (obesity)