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considerable interest exists in identifying these glucose-independent renoprotective actions Data from clinical trials suggest that GLP-1R agonists and, to a lesser extent, DPP-4 inhibitors marginally improve surrogate renal end points, plausibly beyond the effects of improved glycaemic control Abstract The gastrointestinal tract the largest endocrine network in human physiology orchestrates signals from the external environment to maintain neural and hormonal control of homeostasis

doi: 10.1111/obr.13929, 7 Bernosky-SmithK

In the STEP trials, nausea was most common in the first 20 weeks of treatment and declined significantly after that

One in eight Americans are taking or have taken a glucagon-like peptide-1 receptor agonist (GLP-1)