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As expected, treatment with 2-AAPA diminished cellular GSH levels and increased GSSG, thus significantly elevating the GSSG/GSH ratio, similar to the effects of etomoxir (Figure 4B)

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7Ashows immunohistochemistry images of hair cells with nuclei stained in blue (DAPI) and hair cells stained with myosin VIIA ingreen following0 M of cisplatin (first image from left), 10 M of cisplatin for 48 hours (second image from left), 50 M of cisplatin for 48 hours (third image from left), and 10 M of cisplatin for 72 hours (fourth image from left).FIG

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