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Although the FDA has identified a potential safety issue with these medications, the agency says it does not indicate a causal relationship between the drug and the listed risk, according to the The FDA recommends people using GLP-1 drugs for weight loss or diabetes who are concerned about side effects should talk with their healthcare team

Unlike selective serotonin reuptake inhibitors (SSRIs), which often cause weight gain as a side effect, bupropion has a neutral to slightly weight-reducing profile

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Doctors make decisions about long-term semaglutide use by looking at several important factors