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The combination works through multiple pathways

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Composition The compositions of co-formulation 17 and co-formulation 18 are shown in table 16

For example, ER stress activates DNA damage inducible transcript 3 (DDIT3, also known as CHOP)- and mitogen-activated protein kinase 8 (MAPK8, also known as JNK)-dependent apoptosis pathways, whereas heat shock protein family A member 5 (HSPA5, also known as BIP) SSG at Cys420/441 modulates ATPase activity and protein folding, paradoxically suppressing apoptosis 49

However, peptide therapy for rheumatoid arthritis is still considered an emerging area of research