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Embodiment 3 [0037] N-protected-L-histidine (6.20g, 0.01mol) was added to the reaction flask, thionyl chloride (11.9g, 0.1mmol) was heated to reflux, N,N-dimethylformamide (30mL) was added, Control the temperature and reflux

More severe GI side effects were seen in oral administration, and injections were associated with irritation at sites of administration [1]

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This extended activity is key to their therapeutic efficacy, enabling once-weekly dosing for many of these medications