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FDA approval for Zepbound in treating sleep apnea was based on two previous Eli Lilly-sponsored trials published in the New England Journal of Medicine involving nearly 470 participants, some of whom were using continuous positive airway pressure (CPAP) machines, a standard treatment for OSA

This creates a tension between therapeutic intensity and tolerability that is less pronounced in diabetes care

doi: 10.3390/diagnostics15172264 Masulli M, Tack J, Esposito G, Sarnelli G

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Key documentation to prepare: 6+ months of weight management records (dietitian visits, gym membership, food logs), lab work showing relevant biomarkers (A1C, lipid panel, blood pressure), a letter of medical necessity from your prescriber explaining why tirzepatide specifically is needed over alternatives, and any records of prior medication trials that were inadequate