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The structures with especially sacred functions were often located in a sacred precinct at the center of the city which was, like the Ciudadela, symbolically "the center of the world, the point of intersection of all the world's paths, both terrestrial and celestial,"17 the point at which the breakthrough in plane of which Eliade spoke was possible and therefore the location of the temple in which the priest or ruler could communicate with the world of the spirit

There is one sore point, though: the adjustment dial remains internal

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Persistent oxidative stress induces mitochondrial fragmentation and genomic adaptation, while activation of the AKTGSK3NRF2 axis stabilizes antioxidant defenses