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Figure 1 2 Pathogenesis of RA RA is an inflammatory disease caused by multi-cells communication and interaction by cytokines, which result in a variety of pathological reactions ( The cell-cell contact or cytokine signals from antigen-presenting cells (APCs) (especially Dendritic cells, DC) induced the conversion of T cells, B cells, synovial fibroblasts, osteoclasts and osteoblasts

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