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H152 and active site residues C46, K48, Q81, and W136 are highlighted and shown as sticks

Also, they remark on the relevance of neuroactive steroids synthesized by the placenta at the very early developmental stages as major regulators of neurodevelopmental processes ( Glucocorticoids exert key functions in the CNS and play a fundamental role in pregnancy at late stages

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These interactions make DSIP a promising candidate for research on chronic pain and the mechanisms of dependence.DSIP and opioids, 1984, PMID 6548970