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Growth factor-mediated recovery research also investigates IGF-1 LR3, which acts downstream of GH signaling to directly activate insulin-like growth factor receptor pathways in target tissues

doi: 10.1007/s00018-023-05024-y [DOI] [PMC free article] [PubMed] [Google Scholar] 6

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However, when used chronically or at higher doses, that slowed motility can evolve into functional paralysis of the stomach, the hallmark of gastroparesis