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After reviewing these relevant studies, 13 studies demonstrated that lycopene could significantly refine the clinical manifestations of OSF patients, among which 12 randomized controlled trial (RCT) studies have compared the potential efficacy between lycopene and other treatment modalities or the combinational effectiveness of lycopene with other drugs, apart from one study by Arakeri et al

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Patients must also consider the financial implications, as off-label use may not be NHS-funded, potentially incurring substantial private costs