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Once intended as a policy response to reduce harm suffered by people who have long-term addictions to intravenous drugs such as heroin, such sites are now being visited by Gen Z TikTokers

This "paradoxical response" (where treatment temporarily makes symptoms worse) includes: Numbness and tingling Shooting pains Joint pain Increased sensitivity Temporary inflammation (swelling and irritation) While these symptoms generally indicate that treatment is working (as nerves begin to repair themselves), they can be distressing for patients and may require additional treatment for comfort

IV protocols require more careful titration

For patients, this distinction matters

35 The nerve fibers innervating the painful degenerated IVDs are primarily small unmyelinated neurons expressing the neural growth associated protein (GAP)43 and coexpress the neuropeptide substance P (SP) that confirm their nociceptive identity