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If there is a lack of cobalamin in the body, methylmalonyl CoA accumulates, which presumably leads to the neurological manifestations of B12 deficiency

Learn how long B12 stays good, how to extend shelf life, and what happens after the expiration date

View image online ( Illustration of person holding a sign that says Vitamin B12, with B12 foods like eggs, nuts and cheese floating around If you want to increase your intake of vitamin B12, put down that bottle of vitamins

A B12 injections effect can last anywhere from a couple of weeks to a few months, and the difference comes down to why you are deficient, how well your body holds on to B12, and the dose and schedule you are on