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Adults: Initially, 50 mg/500 mg or 50 mg/1000 mg twice daily based on dose of metformin already being taken

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Selenium is a cofactor for enzymes that are present in thyroid cells, such as iodothyronine deiodinase (DIO), which catalyzes the conversion of T4 to T3, thioredoxin reductase (TR), which is involved in the regulation of the redox state, and glutathione peroxidase (GPx), which catalyzes the reduction of H 2 O 2 to H 2 O, using reduced glutathione (GSH) as a cosubstrate

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Psychiatry 59 , 2233 (1998)

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