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Causes and Mechanisms While estrogen deficiency is the primary trigger, it does not fully explain the experience of hot flashes

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Other factors, such as the drugs tendency to cause low blood sugar (hypoglycemia), interactions with other medications, and potential for severe side effects, may also result in an increased risk of the condition

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GLP-1 receptors are expressed in the heart muscle cells, immune system cells in the heart, and in the lining of blood vessels.[ref] GLP-1 RAs have been shown to help in heart failure and also to have beneficial effects on heart rhythm.[ref] Related article : Cardiovascular disease genetic risk factors Cancer Research: Retatrutide, a GLP-1/GIP/GCG triple agonist, has recently been shown to reduce pancreatic tumor mass in animals