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[DOI] [PMC free article] [PubMed] [Google Scholar] 225.Liu J, et al
Across the three doses of tirzepatide, all patients achieved this composite endpoint in a significantly greater percent compared to patients on semaglutide, with a satisfactory safety profile [25]
Glucagon receptor activation: Increases hepatic glucose output (relevant in fasted states), stimulates lipolysis in adipose tissue, and raises basal metabolic rate through thermogenic mechanisms
Mediation analysis supports a causal relationship between maternal hyperglycemia and placental DNA methylation variations at the leptin gene locus and cord blood leptin levels
Most cases are mild and improve with time
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