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The World Health Organization (WHO) reports the worldwide death toll from tobacco use is 4 million annually

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For example, imbalanced levels of zinc have an impact on the development of certain lung diseases

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However, as IVW can be sensitive to heterogeneity and horizontal pleiotropy, we performed additional sensitivity analyses using complementary MR methods, including MR-Egger regression, the weighted median method, and the weighted mode estimator, to evaluate the robustness of our findings and to account for potential violations of the MR assumptions